Thermo Fisher Scientific Human LGI3 Synthetic Peptide
인간 LGI3 단백질의 중심부 12개 아미노산 서열 기반 합성 펩타이드로, 항체 차단 실험에 사용 가능. PBS 버퍼와 BSA 포함, 200 µg/mL 농도로 제공. 연구용으로만 사용하며 안정적인 보관을 위해 -20°C에서 저장.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 12 amino acids near the center of human LGI3.
PEP-0614 can be used as a blocking peptide with polyclonal antibody PA5-20494.
Target Information
The leucine-rich, glioma inactivated gene 3 (LGI3) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four highly related proteins containing leucine-rich repeats (LRRs), which are similar to other transmembrane signaling molecules and receptors.
LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms.
Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI3 have not been found to be associated with ADTLE. LGI3 expression is induced in rat astrocyte cultures by the amyloid beta (Abeta) peptide and accumulated on neuronal plasma membranes of aged monkey brains, co-localized with Abeta.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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