Thermo Fisher Scientific cGAS Polyclonal Antibody
cGAS 단백질을 인식하는 Thermo Fisher Scientific의 고순도 rabbit polyclonal 항체. Western blot에 적합하며 인간 및 랫트 반응성. 항원 친화 크로마토그래피로 정제, 1 mg/mL 농도. 선천면역 연구용으로 권장.
- 카탈로그번호
- PA576367
- 판매단위
- pk
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Thermo Fisher Scientific cGAS Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:2,000
Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide of human C6orf150 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2720094 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
cGAS (Cyclic GMP-AMP synthase) is a nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP, playing a key role in innate immunity.
Catalysis involves formation of both 2’,5’ and 3’,5’ phosphodiester linkages, producing c[G(2’,5’)pA(3’,5’)p] responses.
cGAS directly binds cytosolic DNA, activating synthesis of cGAMP. This second messenger binds and activates TMEM173/STING, triggering type-I interferon production.
cGAS is also involved in detection of bacterial DNA, cellular stress responses, DNA damage recognition, and regulation of cellular senescence.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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