Thermo Fisher Scientific BCCIP Polyclonal Antibody

Thermo Fisher Scientific BCCIP Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended positive controls: A431, HeLa
• Store product as a concentrated solution.
• Centrifuge briefly prior to opening the vial.

Target Information

BCCIP was identified through its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal region shares moderate homology with calmodulin and M-calpain, suggesting calcium-binding capability. Functional studies indicate its role as a BRCA2 cofactor in tumor suppression and as a modulator of CDK2 kinase activity via p21. It is also involved in BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.