Thermo Fisher Scientific PNMA2 Monoclonal Antibody (2D4)
PNMA2 단백질을 표적하는 Thermo Fisher Scientific의 마우스 단일클론 항체(2D4)로, Western blot과 ELISA에 적합합니다. 인간 시료 반응성이 있으며, PBS(pH 7.4) 용액 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific PNMA2 Monoclonal Antibody (2D4)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 1 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2D4 |
| Immunogen | PNMA2 (AAH62301, 1–364 a.a.) full-length recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MALALLEDWC RIMSVDEQKS LMVTGIPADF EEAEIQEVLQ ETLKSLGRYR LLGKIFRKQE NANAVLLELL EDTDVSAIPS EVQGKGGVWK VIFKTPNQDT EFLERLNLFL EKEGQTVSGM FRALGQEGVS PATVPCISPE LLAHLLGQAM AHAPQPLLPM RYRKLRVFSG SAVPAPEEES FEVWLEQATE IVKEWPVTEA EKKRWLAESL RGPALDLMHI VQADNPSISV EECLEAFKQV FGSLESRRTA QVRYLKTYQE EGEKVSAYVL RLETLLRRAV EKRAIPRRIA DQVRLEQVMA GATLNQMLWC RLRELKDQGP PPSFLELMKV IREEEEEEAS FENESIEEPE ERDGYGRWNH EGDD
Target Information
In patients with cancer, symptoms of limbic and brain-stem dysfunction may result from a paraneoplastic disorder. Two proteins, Ma1 and Ma2, were discovered by the presence of autoantibodies against them. Antibodies to Ma1 and Ma2 proteins identify a paraneoplastic disorder that affects the limbic system, brain stem, and cerebellum. These autoantibodies were used to clone Ma2, which codes for a protein recognized by serum from affected patients but not by control subjects. Ma2 is selectively expressed in normal brain tissue and testicular tumors, and shares homology with Ma1, a brain-testis-cancer gene related to other paraneoplastic syndromes and tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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