Thermo Fisher Scientific Phospho-4EBP1 (Thr70) Polyclonal Antibody
인간 4E-BP1 단백질의 Thr70 인산화 부위를 인식하는 폴리클로날 항체입니다. IHC(P)에서 1:50~1:100 희석으로 사용 가능하며, 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 -20°C에서 보관합니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- PA537558
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around phosphorylation site of threonine70 (T-K-T(p)-P-P) derived from Human 4E-BP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554166 |
Product Specific Information
- A suggested positive control for IHC is human colon carcinoma.
Target Information
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E, which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5′ end of mRNAs.
Interaction of this protein with eIF4E inhibits complex assembly and represses translation.
This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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