Thermo Fisher Scientific MRPL40 Polyclonal Antibody
Rabbit polyclonal antibody targeting human MRPL40, validated for WB and IHC(P). Supplied unconjugated in liquid form at 1 mg/mL. Suitable for mitochondrial ribosomal protein studies. For research use only.
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- PA538965
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- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from the internal region of human MRPL40 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555557 |
Target Information
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and play a role in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit, with an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Unlike prokaryotic ribosomes, mammalian mitoribosomes lack a 5S rRNA. The proteins comprising the mitoribosome differ greatly among species in sequence and biochemical properties, making recognition by sequence homology difficult. The MRPL40 gene encodes a 39S subunit protein, and deletions in this gene may contribute to velo-cardio-facial syndrome and DiGeorge syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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