Thermo Fisher Scientific DMTF1 Polyclonal Antibody
DMTF1 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. Human, Mouse, Rat 시료에 반응하며, Protein A로 정제된 고순도 항체. -20°C에서 보관하며 연구용으로 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human DMTF1 (amino acids 101–200) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The DMTF1 gene encodes a transcription factor containing a cyclin D-binding domain, three central Myb-like repeats, and acidic transactivation domains at both termini. It is induced by oncogenic Ras signaling and acts as a tumor suppressor by activating the ARF-p53 pathway to arrest cell growth or induce apoptosis. DMTF1 also activates aminopeptidase N transcription and may play a role in hematopoietic cell differentiation. The gene is hemizygously deleted in about 40% of human non-small-cell lung cancer, making it a potential prognostic and gene-therapy target. Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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