Thermo Fisher Scientific Factor 12 heavy chain Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:300

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: Assay-dependent

Product Specifications

Target Information

Hemostasis following tissue injury involves the deployment of essential plasma procoagulants which are involved in a blood coagulation cascade leading to the formation of insoluble fibrin clots and the promotion of platelet aggregation.
Factor XII (FXII), a blood coagulation factor, is a serum glycoprotein that participates in fibrinolysis, as well as the generation of bradykinin and angiotensin.
As a serine protease, it activates both Factor XI and prekallikrein in the coagulation cascade.
Factor XII deficiency, a rare hereditary disorder slightly more prevalent among Asians, does not cause excessive hemorrhaging since other coagulation factors compensate for it.
However, Factor XII deficiency has been reported as a risk factor for arterial and venous thromboembolism.
The gene for human Factor XII maps to the long arm of chromosome 5 (5q33–qter).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.