Thermo Fisher Scientific Centaurin beta 2 Polyclonal Antibody
Centaurin beta 2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Human, Mouse, Rat에 반응합니다. Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합하며 Protein A로 정제된 고순도 항체입니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Centaurin beta 2 (amino acids 101–200) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
ACAP2 is a transport carrier belonging to the Centaurin family with three ANK repeats, an Arf-GAP domain, a BAR domain, and a PH domain. ACAP2 functions as a GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) and exhibits strong constitutive ARF6 GAP activity. This activity is stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid, but shows little activity toward ARF1. ACAP2 controls the return of ARF to the inactive GDP-bound state. Together with ACAP1, ACAP2 is targeted by phosphatidylinositol (3,4,3) triphosphate, inhibiting PDGF-induced dorsal membrane ruffles in NIH3T3 fibroblasts when overexpressed. ACAP2 is phosphorylated upon DNA damage, likely by ATM or ATR, and is widely expressed, with the highest levels in lung tissue.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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