Thermo Fisher Scientific APS Polyclonal Antibody
Thermo Fisher Scientific의 APS Polyclonal Antibody는 마우스 APS 단백질을 검출하는 토끼 IgG 폴리클로날 항체입니다. Western blot과 Immunocytochemistry에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용 전용으로 다양한 세포 신호전달 연구에 활용 가능합니다.
- 카탈로그번호
- PA11062
- 판매단위
- pk
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500 | - |
| Immunocytochemistry (ICC/IF) | 1:250 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues E(605) A T L G R A R A V E N Q Y S(619) from mouse APS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2188849 |
Product Specific Information
PA1-1062 detects APS from mouse samples.
It has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~84 kDa protein corresponding to APS from recombinant mouse protein and 3T3L1 extracts.
The immunogen is a synthetic peptide corresponding to residues E(605) A T L G R A R A V E N Q Y S(619) from mouse APS.
This peptide (Cat. # PEP-246) can be used in neutralization and control experiments.
Target Information
APS (adapter protein with Pleckstrin homology and Src homology 2 domains) is a member of the Lnk family and acts as an adaptor protein involved in B-cell signaling, insulin signaling, and cytoskeletal reorganization.
It is tyrosine phosphorylated by JAK2, KIT, and other kinases during B-cell receptor stimulation by various cytokines, chemokines, and leukokines.
APS inhibits the JAK-STAT pathway in collaboration with c-Cbl.
It localizes to the cytoplasm in pre-PDGF-stimulated cells and relocates to the plasma membrane upon PDGF stimulation.
APS is expressed in B-cells and mast cells, as well as in spleen, prostate, testis, uterus, small intestine, and skeletal muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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