Thermo Fisher Scientific SLC39A2 Polyclonal Antibody
Human SLC39A2 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:20–1:50 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS(40% glycerol) 버퍼에 보존. ZIP2 단백질 연구용으로 적합.
- 카탈로그번호
- PA556486
- 판매단위
- pk
카탈로그
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:20–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SLC39A2. Recombinant protein control fragment (Product #RP-89135) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2647501 |
Product Specific Information
Immunogen sequence:
QCCPGAAGGS TVQDEEWGGA HIFELHSHGH LPSPS
Highest antigen sequence identity to the following orthologs:
- Mouse: 71%
- Rat: 71%
Target Information
The zinc transporter ZIP2, also known as SLC39A2, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in growth, development, and differentiation.
Similar to knock-outs of ZIP1 and ZIP3, ZIP2⁻ mice show no phenotypic differences compared to wild-type mice. However, when ZIP1, ZIP2, and ZIP3 genes are all eliminated and these mutant mice are fed a zinc-deficient diet, abnormalities such as reduced embryonic membrane-bound alkaline phosphatase activity and abnormal development occur. This indicates that ZIP1–3 proteins play an important, noncompensatory role under zinc-deficient conditions.
Recent studies show that ZIP2 and ZIP3 are downregulated in human prostate adenocarcinomatous glands, suggesting their importance in zinc retention within cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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