Thermo Fisher Scientific IDO Monoclonal Antibody (C14)
IDO1 단백질을 표적으로 하는 C14 클론의 Mouse Monoclonal Antibody. Western Blot, IHC, ICC/IF에 적합하며 Human 및 Pig 반응성 확인. 고순도 Protein A/G 정제, PBS/glycerol buffer에 보존. 연구용으로만 사용.
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Thermo Fisher Scientific IDO Monoclonal Antibody (C14)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.01–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–30 µg/mL |
| Immunocytochemistry (ICC/IF) | 5–30 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Pig |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | C14 |
| Immunogen | Recombinant Human IDO protein, Ala2–Gly403 (Accession #P14902) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.05% Proclin 300 |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3090577 |
Target Information
IDO1 is an intracellular heme-containing enzyme that catalyzes the oxidative cleavage of the indole ring of several important regulatory molecules such as tryptophan, serotonin, and melatonin. This reaction initiates the production of biologically active metabolites known as kynurenines.
IDO1 is widely expressed in human tissues, macrophages, and dendritic cells. During inflammation, interferons (IFNs) induce IDO1 expression, contributing to antimicrobial defense by depleting tryptophan and inhibiting pathogen growth. Additionally, IDO1 plays a crucial role in immunoregulation during infection, pregnancy, autoimmunity, transplantation, and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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