Thermo Fisher Scientific Arginase 1 Monoclonal Antibody (C7)
Arginase 1 단백질을 특이적으로 인식하는 C7 클론의 Mouse Monoclonal Antibody. Western blot, IHC, ICC 등 다양한 응용 가능. Human 및 Pig 시료 반응성 확인. 고순도 Protein A/G 정제, 장기 보관 시 -20°C 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 5–20 µg/mL |
| Immunocytochemistry (ICC/IF) | 5–20 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Pig |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | C7 |
| Immunogen | Recombinant Human ARG protein, Met1–Lys322 (Accession #P05089) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.05% Proclin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3093437 |
Target Information
Arginase-1 (Arg1) is a 35 kDa enzyme that converts L-arginine to urea and L-ornithine, completing the final step in the urea cycle. The resulting polyamines are essential for cell proliferation and detoxification of protein degradation byproducts.
By degrading arginine, Arginase 1 reduces substrate availability for nitric oxide synthase, thereby down-regulating nitric oxide production.
In both human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid-derived suppressor cells (MDSCs), and neural stem cells.
Human expression occurs in blood neutrophils but not in CCR3+ granulocytes. In mice, Arginase 1 is a hallmark of alternatively activated macrophages (M2a).
Arginase-1 may also be expressed in myeloid cells infiltrating tumors and is typically found in most hepatocellular carcinomas.
Defects in Arginase 1 cause argininemia, an autosomal recessive disorder characterized by hyperammonemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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