Thermo Fisher Scientific Arginase 1 Monoclonal Antibody (C7)

Applications and Tested Dilutions

Product Specifications

Target Information

Arginase-1 (Arg1) is a 35 kDa enzyme that converts L-arginine to urea and L-ornithine, completing the final step in the urea cycle. The resulting polyamines are essential for cell proliferation and detoxification of protein degradation byproducts.
By degrading arginine, Arginase 1 reduces substrate availability for nitric oxide synthase, thereby down-regulating nitric oxide production.

In both human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid-derived suppressor cells (MDSCs), and neural stem cells.
Human expression occurs in blood neutrophils but not in CCR3+ granulocytes. In mice, Arginase 1 is a hallmark of alternatively activated macrophages (M2a).
Arginase-1 may also be expressed in myeloid cells infiltrating tumors and is typically found in most hepatocellular carcinomas.
Defects in Arginase 1 cause argininemia, an autosomal recessive disorder characterized by hyperammonemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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