Thermo Fisher Scientific PSMA1 Monoclonal Antibody (OTI9H1), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:250

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100

Product Specifications

Target Information

Proteolytic degradation is critical to maintaining appropriate levels of short-lived and regulatory proteins involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signaling factors.
The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus, while others are degraded via the vacuolar pathway (endosomes, lysosomes, and endoplasmic reticulum).

The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine (~2.5 MDa). It consists of a 20S proteolytic core complex crowned by one or two 19S regulatory subunit complexes. The 19S subunits recognize ubiquitinated proteins and are essential for unfolding and translocating targets into the 20S lumen.

An enzymatic cascade attaches multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Genetic diseases associated with defects in this pathway include cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.