Thermo Fisher Scientific Perforin Polyclonal Antibody
Human, Mouse, Rat 반응성을 가진 Rabbit Polyclonal Perforin 항체로, WB, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. KLH 결합 합성 펩타이드(aa 22-100)로 면역화. Protein A 정제, 1 mg/mL 농도, -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Perforin (amino acids 22–100) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Perforin is one of the major cytolytic proteins found in cytolytic granules. It acts as a cytolytic mediator stored and released by cytoplasmic granules and plays a key role in immune defense against tumors and viral infections mediated by cytotoxic lymphocytes.
Perforin consists of 555 amino acids, including a 21-amino-acid signal peptide, and has a molecular weight of approximately 70–75 kDa. It is a pore-forming protein with a mechanism similar to complement component C9, showing significant homology. Expression is restricted to killer cell lines, not helper T lymphocytes or other tumor cells. Mutations in the perforin gene can cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing produces multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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