Thermo Fisher Scientific ERK5 Polyclonal Antibody
ERK5/BMK1 단백질의 334-349번 잔기에서 유래한 합성 펩타이드로 제작된 Rabbit Polyclonal Antibody. 인간, 마우스, 랫트 반응성. WB 검증 완료. 항원 친화 크로마토그래피로 정제된 액상 항체로, -20°C 보관. 연구용으로만 사용.
- 카탈로그번호
- 44688G
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Chemically synthesized peptide derived from residues 334–349 of human ERK5/BMK1 protein. Full-length ERK5/BMK1 has a molecular weight of ~88 kDa; truncated versions of ~30–35 kDa have also been observed. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS (pH 7.3) with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533723 |
Target Information
MAPK7 (ERK5) serine/threonine kinase is a member of the MAP kinase family and is involved in diverse cellular processes such as proliferation, differentiation, transcription regulation, and development.
MAPK7 is activated by MAP2K5/MEK5 and participates in downstream signaling of various receptors.
Upon extracellular stimulation, MAPK7 translocates to the nucleus to regulate gene expression through phosphorylation and activation of transcription factors.
Gene deletion of MAPK7 in mice leads to defective blood vessel and cardiac development, resulting in embryonic lethality.
MAPK7 is critical for endothelial function and blood vessel integrity.
Four alternatively spliced transcript variants encoding two distinct isoforms have been reported.
ERK5 is expressed in many adult tissues, abundantly in heart, placenta, lung, kidney, and skeletal muscle, but not detectable in liver.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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