Thermo Fisher Scientific Phospho-Progesterone Receptor (Ser190) Monoclonal Antibody (1154)

Applications and Tested Dilution

Product Specifications

Product Specific Information

37-8200 detects Phospho-Progesterone Receptor in human samples.
It has been successfully used in western blot, immunofluorescence, and immunohistochemistry.
Phospho-Progesterone Receptor (Ser190) antibody detects both progesterone receptor A and B forms when phosphorylated at Ser26 and Ser190, respectively.

Target Information

The progesterone receptor (PR) is a member of the steroid family of nuclear receptors.
It mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy.

PR exists as:

• Form A (94 kDa)
• Form B (120 kDa)

These forms arise from alternative translation initiation sites.
PR-B is transcriptionally active and responsible for activating genes involved in endometrial maintenance, pregnancy, and ovulation inhibition.
PR-A lacks 165 amino acids at the N-terminus, exposing an inhibitory domain that represses steroid hormone transcriptional activity.

In its inactive state, PgR forms a multiprotein complex with heat shock proteins and immunophilins.
Upon binding progesterone, the receptor undergoes conformational change, dimerizes, and binds to progesterone response elements (PRE) to activate transcription.
A null mutation in the PGR gene causes reproductive abnormalities.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.