Thermo Fisher Scientific Phospho-Progesterone Receptor (Ser190) Monoclonal Antibody (1154)
인간 시료에서 인산화 프로게스테론 수용체(Ser190)를 검출하는 마우스 단클론 항체. WB, IHC, ICC/IF에 사용 가능. Protein G 정제, 보존제 없음. -20°C 보관, 동결/해동 반복 피해야 함.
- 카탈로그번호
- 378200
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (IHC) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1154 |
| Immunogen | Synthetic phospho peptide derived from a region of the human Progesterone Receptor (hPR) protein surrounding the phosphorylated Ser190 residue. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein G |
| Storage buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 50% glycerol, 100µg/mL BSA |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533343 |
Product Specific Information
37-8200 detects Phospho-Progesterone Receptor in human samples.
It has been successfully used in western blot, immunofluorescence, and immunohistochemistry.
Phospho-Progesterone Receptor (Ser190) antibody detects both progesterone receptor A and B forms when phosphorylated at Ser26 and Ser190, respectively.
Target Information
The progesterone receptor (PR) is a member of the steroid family of nuclear receptors.
It mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy.
PR exists as:
- Form A (94 kDa)
- Form B (120 kDa)
These forms arise from alternative translation initiation sites.
PR-B is transcriptionally active and responsible for activating genes involved in endometrial maintenance, pregnancy, and ovulation inhibition.
PR-A lacks 165 amino acids at the N-terminus, exposing an inhibitory domain that represses steroid hormone transcriptional activity.
In its inactive state, PgR forms a multiprotein complex with heat shock proteins and immunophilins.
Upon binding progesterone, the receptor undergoes conformational change, dimerizes, and binds to progesterone response elements (PRE) to activate transcription.
A null mutation in the PGR gene causes reproductive abnormalities.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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