Thermo Fisher Scientific FGF4 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total FGF4.

Target Information

Fibroblast growth factor 4 (FGF4) is a member of the fibroblast growth factor (FGF) family that possesses broad mitogenic and cell survival activities. It plays key roles in growth and survival of stem cells during embryogenesis, tissue regeneration, and carcinogenesis.
FGF4 was identified by its strong oncogenic transforming activity and acts as a potent angiogenic factor, expressed in several highly vascularized tumors and in adult mouse testis, intestine, and brain.
Studies on the mouse homolog suggest a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. Furthermore, FGF4 regulates neural progenitor cell proliferation and neuronal differentiation.
Recent studies show a growth-promoting role for FGF4 in human embryonic stem cells and a putative feedback inhibition mechanism by a novel FGF4 splice isoform that may serve to promote differentiation at later stages of development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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