Thermo Fisher Scientific WRN Polyclonal Antibody
WRN 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF 실험에 적합합니다. 인간 및 마우스 시료에 반응하며, 고순도의 affinity chromatography 정제 항체입니다. DNA 수선 및 복제 관련 연구에 활용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human WRN (Accession Q14191), corresponding to amino acid residues L927–F977 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852445 |
Product Specific Information
Antibody detects endogenous levels of total WRN.
Target Information
This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair.
This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses intrinsic 3′ to 5′ DNA helicase activity and is also a 3′ to 5′ exonuclease.
Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double-strand DNA breaks.
Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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