Thermo Fisher Scientific HMGN3 Polyclonal Antibody
HMGN3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. WB, IHC, IP 등 다양한 응용 가능. 액상 형태로 4°C 보관, 1년 권장 보관기간. 인간 및 오랑우탄에 반응 예측. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 60 and 99 of human high mobility group nucleosomal binding domain 3 (HMGN3, UniProt ID: Q15651-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Orangutan
Target Information
HMGN3 binds to nucleosomes, regulating chromatin structure and chromatin-dependent processes such as transcription, DNA replication, and DNA repair.
It affects insulin and glucagon levels and modulates pancreatic gene expression related to insulin secretion.
Regulates the expression of glucose transporter SLC2A2 by binding to its promoter region and recruiting PDX1 and other transcription factors.
Also regulates SLC6A9, a glycine transporter affecting synaptic glycine concentration in the CNS.
May play roles in ocular development and astrocyte function.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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