Thermo Fisher Scientific NSD1 Recombinant Rabbit Monoclonal Antibody (1B1)
Human NSD1 단백질을 표적으로 하는 재조합 토끼 단일클론 항체로, ICC/IF 및 ChIP 분석에 적합합니다. HEK293 세포에서 발현되었으며, Protein A로 정제된 액상 형태입니다. 핵 내 NSD1 검출에 높은 특이성과 재현성을 제공합니다.
- 카탈로그번호
- MA544597
- 판매단위
- pk
카탈로그
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100
- Publications: References
ChIP assay (ChIP)
- Tested Dilution: 5 µg
- Publications: References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 1B1 |
| Immunogen | Recombinant protein within human NSD1 aa 1-200 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 0.1% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931057 |
Product Specific Information
- Predicted band size: 297 kDa
- Positive Control: HEK293
- Subcellular Location: Nucleus
Target Information
This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region.
The encoded protein enhances androgen receptor (AR) transactivation, which can be further increased in the presence of AR-associated coregulators.
This protein may act as a nucleus-localized transcriptional factor and bifunctional transcriptional regulator.
Mutations of this gene are associated with Sotos syndrome and Weaver syndrome.
A subtype of childhood acute myeloid leukemia results from a cryptic translocation involving NSD1 (chromosome 5) and nucleoporin 98-kd (chromosome 11).
Two transcript variants encoding distinct isoforms have been identified.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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