Thermo Fisher Scientific TAS2R3 Polyclonal Antibody
Rabbit polyclonal antibody targeting human TAS2R3, a bitter taste receptor protein. Suitable for WB, IHC, and ICC/IF applications. Lyophilized form; reconstitute in sterile water. For research use only; not for diagnostic purposes.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 200–250 of human TAS2R3 conjugated to blue carrier protein was used as the antigen. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2271568 |
Product Specific Information
- Glycerol (1:1) may be added for additional stability.
- Reconstitute in 100 µL of sterile water.
Target Information
This gene encodes a member of a family of candidate taste receptors that belong to the G protein-coupled receptor superfamily. They are specifically expressed by taste receptor cells of the tongue and palate epithelia. These intronless genes encode a 7-transmembrane receptor protein that functions as a bitter taste receptor. The TAS2R3 gene is clustered with three other taste receptor genes on chromosome 7 and is linked to loci influencing bitter perception.
The receptor is gustducin-coupled and implicated in the perception of bitter compounds in the oral cavity and gastrointestinal tract. It signals through PLCB2 and the calcium-regulated cation channel TRPM5. TAS2R3 is expressed in subsets of taste receptor cells of the tongue and palate epithelium, exclusively in gustducin-positive cells, and also in the antrum, fundus, duodenum, and gastric endocrine cells. Several bitter taste receptors can be expressed in a single taste receptor cell.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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