Thermo Fisher Scientific Cathepsin A Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Mouse Cathepsin A/CTSA.

Target Information

The cathepsin family of proteolytic enzymes includes several diverse classes of proteases. Cathepsins B, L, H, K, S, and O comprise the cysteine protease class; cathepsins D and E comprise the aspartyl protease class; and cathepsin G belongs to the serine protease class.
Cathepsins function in cellular metabolism and participate in peptide biosynthesis and protein degradation. Cathepsin A, a serine carboxypeptidase, exists in a high molecular weight lysosomal complex with β-galactosidase (β-gal) and α-neuraminidase (Neu1). Cathepsin A protects β-gal and Neu1 from intralysosomal proteolysis.
Deficiencies in cathepsin A lead to deficiencies in β-gal and Neu1. The gene encoding human cathepsin A maps to chromosome 20q13.12. Mutations in this gene cause galactosialidosis, a lysosomal storage disorder resulting from β-gal and Neu1 deficiencies.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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