Thermo Fisher Scientific Human FOXO4 Synthetic Peptide
인간 FOXO4 단백질의 N-말단 16 아미노산 서열에 해당하는 합성 펩타이드로, PA5-20974 항체의 블로킹 펩타이드로 사용 가능. 인슐린/IGF1 신호전달 연구에 적합하며, 액상 형태로 제공되고 -20°C에서 보관.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 16 amino acids near the amino terminus of human FOXO4.
PEP-1088 can be used as a blocking peptide with polyclonal antibody PA5-20974.
Target Information
FOXO4 (Forkhead box O4) is encoded by the FOXO4 gene located on the X chromosome.
It is also known as AFX1 or MLLT7 (Myeloid/Lymphoid or Mixed-Lineage Leukemia (Trithorax Homolog, Translocated To, 7)) and is a member of the O class of forkhead/winged helix family of transcription factors along with FOXO1, FOXO3, and FOXO6.
FOXO4 is abundantly expressed in skeletal muscle and adipose tissue. It binds to the Insulin Responsive Element (IRE) and activates downstream targets of Insulin/IGF1 signaling such as IGFBP1.
Activation of another downstream target, Akt, leads to phosphorylation of FOXO4 on specific Ser/Thr residues, which mediates binding of FOXO4 to 14-3-3 and its exit from the nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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