Thermo Fisher Scientific CD18a Monoclonal Antibody (PNK-I)
Thermo Fisher Scientific의 CD18a Monoclonal Antibody (PNK-I)는 돼지 CD18a를 특이적으로 인식하는 마우스 IgG1 단일클론 항체입니다. Flow Cytometry, Immunoprecipitation, Functional Assay에 사용 가능하며, Protein G 정제된 액상 형태로 제공됩니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Flow Cytometry (Flow) | 1:50–1:200 |
| Immunoprecipitation (IP) | Assay-dependent |
| Functional Assay (Functional) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Pig |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PNK-I |
| Immunogen | Porcine large granular lymphocytes |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745268 |
Additional Formats
Product Specific Information
Mouse anti-Pig CD18a, clone PNK-I recognizes porcine CD18a.
Target Information
CD18 integrin beta 2 subunit is a 90 kDa type I transmembrane protein expressed on all leukocytes.
CD18 combines with integrin molecules CD11a–c to form heterodimers at the cell surface, participating in cell adhesion and signaling.
These heterodimers include:
- αLβ2 (CD11a/CD18, LFA-1)
- αMβ2 (CD11b/CD18, Mac-1, CR3)
- αXβ2 (CD11c/CD18)
- αDβ2 (CD11d/CD18)
These integrins are essential for proper leukocyte migration and intercellular contact.
Absence of CD18 leads to leukocyte adhesion deficiency-1 (LAD1).
CD18 is also targeted by Mannheimia haemolytica leukotoxin, mediating cytolysis.
Defects in the CD18 gene cause LAD1, and two transcript variants encoding the CD18 protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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