Thermo Fisher Scientific MSL1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human MSL1. Recombinant protein control fragment (Product #RP-93537). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:MSL1,uniProtId:Q68DK7-1,ncbiNodeId:9606,antigenRange:335-432,antigenLength:614,antigenImageFileName:PA5-54826_MSL1_Q68DK7-1_Rabbit.svg,antigenImageFileNamePDP:PA5-54826_MSL1_Q68DK7-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2644232

Product Specific Information

Immunogen sequence: FGSTERKTPV KKLAPEFSKV KTKTPKHSPI KEEPCGSLSE TVCKRELRSQ ETPEKPRSSV DTPPRLSTPQ KGPSTHPKEK AFSSEIEDLP YLSTTEMY

Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 95%.

Target Information

Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at Lys-16 (H4K16ac) which is implicated in the formation of higher-order chromatin structure (PubMed:16227571). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at Lys-34 (H2BK34Ub) (PubMed:21726816). This modification in turn stimulates histone H3 methylation at Lys-4 (H3K4me) and Lys-79 (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.