Thermo Fisher Scientific TNNI2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.03–0.1 µg/mL

Product Specifications

Product Specific Information

• This antibody is expected to recognize both reported isoforms (NP_003273.1; NP_001139313.1).
• Tested in Peptide ELISA: antibody detection limit dilution 1:128,000.

Target Information

This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C, and troponin I subunits.
The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction.
Mouse studies show this component is also present in vascular smooth muscle and may play a role in smooth muscle function regulation.
In addition to muscle tissues, this protein is found in corneal epithelium and cartilage, where it inhibits angiogenesis and tumor metastasis, and in mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha.
It also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B.
Alternatively spliced transcript variants have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.