Thermo Fisher Scientific GPRC6A Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 10 µg/mL

Product Specifications

Product Specific Information

Percent identity with other species by BLAST analysis:
Human, Gorilla, Monkey, Marmoset (100%)
Dog, Hamster, Elephant (82%)

Target Information

GPRC6A is an Orphan-U GPCR with an unknown ligand. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. Various activating ligands influence GPCR conformation, leading to signaling via G-proteins and downstream effectors. Studies also highlight mechanisms of negative regulation of GPCRs, which have significant physiological implications and drive pharmacological research for new drug candidates. Notable GPCR-targeted drugs include Zyprexa (Eli Lilly) and Claritin (Schering-Plough).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 없음)