Thermo Fisher Scientific MAPKAPK3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:20,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:1,000

Product Specifications

Product Specific Information

• Recommended positive controls: H1299, HeLaS3, mouse spleen
• Predicted reactivity: Mouse (96%), Rat (96%), Zebrafish (85%), Pig (98%), Chicken (93%), Rhesus Monkey (100%), Bovine (98%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

MAPKAPK3 functions as an integrative element of signaling in both mitogen and stress responses. It acts as a mitogen-activated protein kinase (MAP kinase)-activated protein kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), serve as integration points for multiple biochemical signals. MAPKAPK3 is activated by growth inducers and stress stimulation. In vitro studies show that ERK, p38 MAP kinase, and Jun N-terminal kinase can phosphorylate and activate this kinase, indicating its role in integrating mitogen and stress signaling pathways. MAPKAPK3 interacts with, phosphorylates, and represses E47, a transcription factor involved in tissue-specific gene expression and cell differentiation.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.