Thermo Fisher Scientific Phospho-KIF1C (Ser1092) Polyclonal Antibody
Rabbit polyclonal antibody recognizing phospho-KIF1C (Ser1092). Validated for WB, IHC, and ICC/IF. Suitable for studying kinesin-mediated intracellular transport and phosphorylation signaling. Supplied as 1 mg/mL liquid, stored at -20°C.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human KIF1C around the phosphorylation site of Ser1092 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903130 |
Target Information
The kinesins constitute a large family of microtubule-dependent motor proteins responsible for the distribution of numerous organelles, vesicles, and macromolecular complexes throughout the cell. Individual kinesin members play crucial roles in cell division, intracellular transport, and membrane trafficking events including endocytosis and transcytosis.
KIF1C is a member of the KIF1/Unc104 family of kinesin-like proteins, involved in the transport of mitochondria or synaptic vesicles in axons. Human KIF1C maps to chromosome 17p13 and encodes a predicted 1,103 amino acid protein with abundant expression in heart and skeletal muscle.
Tyrosine phosphorylation is a putative regulator of KIF1C-mediated retrograde transport of Golgi vesicles to the endoplasmic reticulum. KIF1C can form homodimers and noncovalently associate with 14-3-3 beta, gamma, epsilon, and zeta. In mouse macrophages, KIF1C is required for anthrax lethal toxin resistance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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