Thermo Fisher Scientific APP Monoclonal Antibody (OTI7A10), TrueMAB
인간 APP 단백질을 인식하는 Mouse IgG2b 단일클론 항체로, Western blot 및 IHC에 적합합니다. 고순도 친화 크로마토그래피로 정제되었으며 PBS/BSA/glycerol 버퍼에 보관됩니다. 알츠하이머병 연구용으로 추천됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7A10 |
| Immunogen | Full length human recombinant protein of human APP produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Target Information
Amyloid Precursor Protein (APP) functions as a cell surface kinesin I membrane receptor, mediating axonal transport of beta-secretase and presenilin 1. APP is crucial for neurite growth, neuronal adhesion, and axonogenesis. It is a 100–140 kDa transmembrane glycoprotein with multiple isoforms generated by alternative splicing. Proteolytic cleavage by beta- and gamma-secretases produces beta amyloid, the main component of senile plaques—key histopathologic features of Alzheimer’s disease. Dysregulation of APP processing is also linked to Down’s syndrome, early-onset familial Alzheimer’s disease, and cerebral hemorrhage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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