Thermo Fisher Scientific IL-17Ra Polyclonal Antibody
IL-17Ra 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat에 반응합니다. Western blot, ICC/IF, ELISA에 적합하며, 막 단백질 검출에 유용합니다. PBS/glycerol buffer에 보관되며, -20°C에서 안정적으로 저장 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:4,000 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 5 µg/mL | - |
| ELISA | 1 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein corresponding to amino acids 33–320 of human IL17RA (NP_0551543) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.19 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804277 |
Product Specific Information
- Positive Samples: HL-60, Mouse liver, Mouse kidney, Mouse lung, Mouse thymus, Rat liver
- Cellular Location: Membrane, Single-pass type I membrane protein
Immunogen sequence:
LRLLDHRALV CSQPGLNCTV KNSTCLDDSW IHPRNLTPSS PKDLQIQLHF AHTQQGDLFP VAHIEWTLQT DASILYLEGA ELSVLQLNTN ERLCVRFEFL SKLRHHHRRW RFTFSHFVVD PDQEYEVTVH HLPKPIPDGD PNHQSKNFLV PDCEHARMKV TTPCMSSGSL WDPNITVETL EAHQLRVSFT LWNESTHYQI LLTSFPHMEN HSCFEHMHHI PAPRPEEFHQ RSNVTLTLRN LKGCCRHQVQ IQPFFSSCLN DCLRHSATVS CPEMPDTPEP IPDYMPLW
Target Information
Interleukin 17A (IL-17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It induces maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17RA is a type I membrane glycoprotein that binds IL-17A and IL-17F with low affinity. The IL-17A/IL-17RA pathway is implicated in inflammatory and autoimmune diseases such as rheumatoid arthritis. Mutations in IL-17RA can cause familial candidiasis type 5 (CANDF5), characterized by altered immune responses and impaired fungal clearance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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