Thermo Fisher Scientific KLF1, 2, 4 Polyclonal Antibody
KLF1, 2, 4 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. 인간, 마우스, 랫트 반응성이 있으며 WB 및 IHC(P) 실험에 적합합니다. 고순도 Protein A 정제, 안정적인 액상 포맷으로 연구용에 최적화되어 있습니다.
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Thermo Fisher Scientific KLF1, 2, 4 Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1:200
- Immunohistochemistry (Paraffin) (IHC (P)): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human KLF1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. It is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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배송/결제/교환/반품 안내
배송 정보
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