Thermo Fisher Scientific ROR2 Monoclonal Antibody (OTI3H3), TrueMAB
ROR2 단백질을 인식하는 Mouse monoclonal antibody로 Western blot과 IHC(P)에서 검증됨. Human 시료에 반응하며, Affinity chromatography로 정제된 1 mg/mL 액상 제품. PBS/BSA/glycerol 완충액에 보관하며 -20°C에서 안정적 저장 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3H3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 796–927 of human ROR2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
ROR2 (receptor tyrosine kinase-like orphan receptor 2) is a type I transmembrane protein belonging to the ROR subfamily of cell surface receptors. It is involved in early chondrocyte formation, cartilage development, and growth plate formation. ROR2 is highly expressed during early embryonic development, with expression decreasing significantly after day 16 and remaining low in adult tissues.
Defects in ROR2 are associated with:
- Brachydactyly type B1 (BDB1): Autosomal dominant skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails, with shortened or absent terminal phalanges.
- Robinow syndrome (RRS): Autosomal recessive disorder characterized by skeletal dysplasia, limb bone shortening, spinal defects, brachydactyly, and facial dysmorphism.
The ROR2 protein contains:
- 1 frizzled (FZ) domain
- 1 immunoglobulin-like C2-type domain
- 1 kringle domain
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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