Thermo Fisher Scientific RIM2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human RIM2 protein for IHC applications. High specificity and affinity purified by antigen chromatography. Supplied as liquid, unconjugated form. Ideal for neuroscience and synaptic transmission research.
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: 5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 16 amino acid peptide near the carboxy terminus of human RIM2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551909 |
Product Specific Information
PA5-34557 can be used with blocking peptide PEP-1600.
Target Information
Rab3-interacting molecules (RIMs) are synaptic proteins essential for neuronal transmission and plasticity. Rim1 and Rim2 are expressed in overlapping but distinct patterns throughout the brain. Ablation of either gene is not lethal, but deletion of both results in postnatal mortality due to defective neurotransmitter release. Synapses lacking RIM proteins can release neurotransmitters but fail to respond to normal Ca²⁺ triggers. Like Rim1, Rim2 acts as an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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