Thermo Fisher Scientific HIP1 Monoclonal Antibody (1E9)
HIP1 단백질을 타깃으로 하는 Thermo Fisher Scientific의 단클론 항체(1E9). Western blot 및 ELISA에 적합하며, 인간 시료 반응성. Huntingtin 관련 단백질 연구 및 암 전이 연구에 유용. PBS 용액 형태로 제공되며 보존제 없음.
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Applications
- Western Blot (WB): 1–5 µg/mL
- ELISA: 1 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1E9 |
| Immunogen | HIP1 (NP_005329, 928–1037 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See label |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein sequence:
DSPNLAQLQQ ASRGVNQATA GVVASTISGK SQIEETDNMD FSSMTLTQIK RQEMDSQVRV LELENELQKE RQKLGELRKK HYELAGVAEG WEEGTEASPP TLQEVVTEKE
Target Information
Huntingtin disease, a neurodegenerative disorder, is caused by the expansion of a polymorphic glutamine tract in huntingtin. The Huntingtin Interacting Protein 1 (HIP-1) is a proapoptotic, cargo-specific adaptor protein implicated in the pathogenesis of Huntingtin disease. It plays a role in clathrin coat recruitment to lipid membranes and may contribute to tumorigenesis by promoting the survival of precancerous and cancerous cells. HIP-1 expression is significantly associated with prostate and colon cancer metastasis, making it a potential prognostic marker for these cancers.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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배송 정보
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