Thermo Fisher Scientific HK2 Monoclonal Antibody (4H1)
HK2 단백질을 인식하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (Clone 4H1). Western blot과 ELISA에 최적화되어 있으며, 인간 및 랫트 시료에 반응. Affinity chromatography로 정제된 액상 항체로 연구용으로만 사용 가능.
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Thermo Fisher Scientific HK2 Monoclonal Antibody (4H1)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 0.3 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4H1 |
| Immunogen | HK2 (AAH21116, 818–917 a.a.) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
IVKEVCTVVA RRAAQLCGAG MAAVVDRIRE NRGLDALKVT VGVDGTLYKL HPHFAKVMHE TVKDLAPKCD VSFLQSEDGS GKGAALITAV ACRIREAGQR
Target Information
In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III, and IV.
Hexokinase activity is involved in the first step in several metabolic pathways including phosphorylation of glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway.
Hexokinase is an allosteric enzyme inhibited by its product GLC-6-P.
Hexokinase 2 is the predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle.
Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.
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