Thermo Fisher Scientific PPOX Polyclonal Antibody

Applications

• Western Blot (WB)

Tested Dilution

• 1:500–1:3,000

Product Specifications

Product Specific Information

• Recommended positive controls: A549, HeLa, HCT116
• Predicted reactivity: Mouse (83%), Rat (81%), Bovine (90%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Protoporphyrinogen oxidase (PPOX) is the penultimate enzyme in the heme biosynthetic pathway, catalyzing the 6-electron oxidation of protoporphyrinogen IX to protoporphyrin IX. The PPOX protein localizes to the inner mitochondrial membrane in tissues such as heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas.
Genetic deficiency of PPOX results in variegate porphyria, an autosomal dominant disorder characterized by cutaneous photosensitivity and neurological manifestations. The rare homozygous variant leads to severe PPOX deficiency with early-onset photosensitization, skeletal abnormalities, short stature, mental retardation, and convulsions.

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm. For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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