Thermo Fisher Scientific COL17A1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:3,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

Assay-dependent

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human COL17A1(Accession Q9UMD9), corresponding to amino acid residues M1-P31. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:COL17A1,uniProtId:Q9UMD9-1,ncbiNodeId:9606,antigenRange:1-31,antigenLength:1497,antigenImageFileName:PA5-101001_COL17A1_Q9UMD9-1_Rabbit.svg,antigenImageFileNamePDP:PA5-101001_COL17A1_Q9UMD9-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2850479

Product Specific Information

Antibody detects endogenous levels of total Collagen XVII.

Target Information

COL17A1 is the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein, and a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. COL17A1 is a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Moreover, COL17A1 is localized to tissues containing type I collagen so, like other members of this collagen family, it may serve to maintain the integrity of the extracellular matrix. Diseases associated with COL17A1 dysfunction include epithelial recurrent erosion dystrophy and epidermolysis bullosa.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.