Thermo Fisher Scientific CDT1 Polyclonal Antibody
Zebrafish CDT1 단백질을 인식하는 Rabbit Polyclonal Antibody로서 Western blot에 최적화됨. 핵 내 CDT1 검출용으로 사용 가능하며, 고순도 Affinity Chromatography 정제 및 안정적 액상 형태로 제공. 연구용 전용 제품.
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Thermo Fisher Scientific CDT1 Polyclonal Antibody
Applications
- Western Blot (WB): Tested dilution 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Zebrafish |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within zebrafish aa 200–251 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | TBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2913275 |
Product Specific Information
- Positive Control: Zebrafish whole organization lysates
- Subcellular Location: Nucleus
Target Information
KMT2A is a histone methyltransferase that plays an essential role in early development and hematopoiesis. It acts as a catalytic subunit of the MLL1/MLL complex, which mediates methylation of Lys-4 of histone H3 (H3K4me) and acetylation of Lys-16 of histone H4 (H4K16ac).
Within the MLL1/MLL complex, KMT2A specifically mediates H3K4me, a tag for epigenetic transcriptional activation. It has weak methyltransferase activity alone and requires other complex components for full activity.
KMT2A shows no activity toward histone H3 phosphorylated on Thr-3, less activity toward H3 dimethylated on Arg-8 or Lys-9, and higher activity toward H3 acetylated on Lys-9. It is required for transcriptional activation of HOXA9 and promotes PPP1R15A-induced apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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