Thermo Fisher Scientific MAGI3 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human MAGI3 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:MAGI3,uniProtId:Q5TCQ9-4,ncbiNodeId:9606,antigenRange:897-1037,antigenLength:1481,antigenImageFileName:PA5-64925_MAGI3_Q5TCQ9-4_Rabbit.svg,antigenImageFileNamePDP:PA5-64925_MAGI3_Q5TCQ9-4_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2663569

Product Specific Information

Immunogen sequence: LKVGDHISAVN GQSIVELSHD NIVQLIKDAG VTVTLTVIAE EEHHGPPSGT NSARQSPALQ HRPMGQSQAN HIPGDRSALE GEIGKDVSTS YRHSWSDHKH LAQPDTAVIS VVGSRHNQNL GCYPVELERG PRGFGFSLRG

Highest antigen sequence identity to the following orthologs - mouse 94%, rat 93%.

Target Information

Membrane-associated guanylate kinase with inverted orientation (MAGI3) is a novel, 130 kDa guanylate kinase which is part of a family of multi-PDZ domain containing guanylate kinases. These guanylate kinases are localized to epithelial cell tight junctions. MAGI3 and PTEN/MMAC cooperate to modulate the kinase activity of AKT/protein kinase B (PKB). MAGI3 positions the PTEN/MMAC phosphatase to specific subcellular locations that are involved with the regulation of cell proliferation and survival. MAGI3, as well as other proteins in this family, are made up of an N-terminal guanylate kinase domain, followed by a WW domain, named for two conserved tryptophan residues and first identified as two repeats in mouse YAP65, which is them followed by 5 PDZ domains.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.