Thermo Fisher Scientific MAGI3 Polyclonal Antibody

Thermo Fisher Scientific MAGI3 Polyclonal Antibody

Applications

• Immunocytochemistry (ICC/IF)
  Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
LKVGDHISAVN GQSIVELSHD NIVQLIKDAG VTVTLTVIAE EEHHGPPSGT NSARQSPALQ HRPMGQSQAN HIPGDRSALE GEIGKDVSTS YRHSWSDHKH LAQPDTAVIS VVGSRHNQNL GCYPVELERG PRGFGFSLRG

Highest antigen sequence identity to the following orthologs:

• Mouse: 94%
• Rat: 93%

Target Information

Membrane-associated guanylate kinase with inverted orientation (MAGI3) is a novel, 130 kDa guanylate kinase which is part of a family of multi-PDZ domain containing guanylate kinases. These kinases are localized to epithelial cell tight junctions. MAGI3 and PTEN/MMAC cooperate to modulate the kinase activity of AKT/protein kinase B (PKB). MAGI3 positions the PTEN/MMAC phosphatase to specific subcellular locations involved with regulation of cell proliferation and survival. MAGI3, as well as other proteins in this family, are composed of an N-terminal guanylate kinase domain, followed by a WW domain and five PDZ domains.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지: PA5-64925_MAGI3_Q5TCQ9-4_Rabbit.svg, PA5-64925_MAGI3_Q5TCQ9-4_Rabbit_PDP.jpeg)