Thermo Fisher Scientific CDC37 Polyclonal Antibody
Rabbit polyclonal antibody targeting human CDC37, validated for WB and IP applications. High specificity and affinity purified via antigen chromatography. Supplied as liquid form with 0.2 mg/mL concentration, stored at 4°C. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 324 to 374 of human cell division cycle 37 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
In S. cerevisiae, Cdc37 has been shown to regulate the cell division cycle through its action on cyclin-dependent kinases (CDKs). It is also associated with signaling pathways and kinases unrelated to cell cycle control, including v-Src, casein kinase II, MPS1 kinase, and the sevenless receptor tyrosine kinase.
HSP90 has been shown to interact with many of the same cellular targets as Cdc37. Cdc37 (also known as p50) forms complexes with Src-family kinases (Fyn, Yes, Fes, Lck, Fgr), Raf, and pp60v-src.
Cdc37 functions as a chaperone independently and in concert with HSP90 and is necessary for the binding of HSP90 to Cdk4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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