Thermo Fisher Scientific MGMT Monoclonal Antibody (MT 3.1)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:50

View 15 publications 15 publications

Immunohistochemistry (IHC)

-

View 39 publications 39 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:10-1:20

View 2 publications 2 publications

Immunocytochemistry (ICC/IF)

1:10-1:200

-

Flow Cytometry (Flow)

2 µg/test

View 1 publication 1 publication

ELISA (ELISA)

-

View 1 publication 1 publication

Product Specifications

Published species

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

MT 3.1

Immunogen

Purified recombinant human MGMT protein

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Storage conditions

4° C

Shipping conditions

Wet ice

RRID

AB_10982210

Product Specific Information

MA5-13506 targets MGMT (O-methylguanine-DNA methyltransferase) in FACS, ICC/IF, IHC (P), and WB applications and shows reactivity with Human samples.

The MA5-13506 immunogen is purified recombinant human MGMT protein.

Target Information

O6-Methylguanine-DNA Methyltransferase (MGMT) is an important DNA repair protein involved in tumor cell resistance to the cytostatic activity of chemotherapeutic alkylating agents. This protein is also effective in protecting normal cells against the genotoxic and carcinogenic effects of DNA alkylation. The alkylating drug resistance is caused by MGMT`s ability to remove DNA alkyl groups introduced in the O6 position of guanine. MGMT is expressed in highly variable amounts, depending upon the cell and tissue type, species, and cellular growth characteristics. In addition, MGMT activity varies among groups of tumors and within a particular type of tumor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.