Thermo Fisher Scientific Phospho-IKK-b (Tyr199) Polyclonal Antibody
Phospho-IKK-b (Tyr199) 폴리클로날 항체로, 인간, 마우스, 랫트 시료에서 IKKβ의 인산화 상태를 검출. Western blot 및 IHC(P) 실험에 적합. 항원 친화 크로마토그래피로 정제된 고순도 항체. NF-κB 신호전달 연구용으로 권장.
- 카탈로그번호
- 620-840
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | LLEQQK-Y-TVTVDY |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 25 mM Tris with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Breast carcinoma
- Cellular location: Nucleus
Target Information
Phosphorylation of serine residues on the I-kappa-B proteins by IKK kinases, including IKBKB, marks them for destruction via the ubiquitination pathway, allowing activation of the NF-kappa-B complex.
IKK beta (Inhibitor of nuclear factor kappa-B kinase subunit beta) is a serine kinase essential for NF-κB signaling, activated by inflammatory cytokines, bacterial or viral products, DNA damage, and other cellular stresses.
It functions as part of the canonical IKK complex, phosphorylating inhibitors of NF-κB on critical serine residues, leading to their ubiquitination and degradation. This process releases NF-κB, enabling its nuclear translocation and activation of genes involved in immune response, growth control, and apoptosis protection.
Mutations in the IKK beta gene can cause Immunodeficiency 15 (IMD15).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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