Thermo Fisher Scientific Phospho-IKK-b (Tyr199) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Positive control: Breast carcinoma
• Cellular location: Nucleus

Target Information

Phosphorylation of serine residues on the I-kappa-B proteins by IKK kinases, including IKBKB, marks them for destruction via the ubiquitination pathway, allowing activation of the NF-kappa-B complex.
IKK beta (Inhibitor of nuclear factor kappa-B kinase subunit beta) is a serine kinase essential for NF-κB signaling, activated by inflammatory cytokines, bacterial or viral products, DNA damage, and other cellular stresses.
It functions as part of the canonical IKK complex, phosphorylating inhibitors of NF-κB on critical serine residues, leading to their ubiquitination and degradation. This process releases NF-κB, enabling its nuclear translocation and activation of genes involved in immune response, growth control, and apoptosis protection.
Mutations in the IKK beta gene can cause Immunodeficiency 15 (IMD15).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.