Thermo Fisher Scientific GLP-1 Monoclonal Antibody (53)
GLP-1(9-18) 합성 항원을 기반으로 제작된 인간 반응성 Mouse Monoclonal Antibody. ELISA 및 Western Blot에 적합하며, GLP-1(9-36) amide에 높은 특이성과 친화도를 가짐. Protein A로 정제된 액상 형태로 4°C 암소 보관.
- 카탈로그번호
- ABS0445302
- 판매단위
- pk
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Thermo Fisher Scientific GLP-1 Monoclonal Antibody (Clone 53)
Applications and Tested Dilution
- Western Blot (WB): Assay-dependent
- ELISA (ELISA): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 53 |
| Immunogen | Synthetic GLP-1(9-18) adsorbed onto aluminum hydroxide gel |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.15 mg/mL (lot-dependent, 0.85–1.15 mg/mL) |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2536222 |
Product Specific Information
- Specificity: ABS 044-53-02 binds human GLP-1 (9-36) amide.
Shows less than 2% cross-reactivity with GLP-1 (7-36) amide based on inhibition ELISA. - Reactivity: Binds free GLP-1 (9-36) amide in solution.
Higher affinity for GLP-1 (9-36) amide than ABS 044-49-02, as determined by inhibition assay.
Target Information
GCG is also known as GLP1 or Glucagon.
Glucagon is a 29-amino acid pancreatic hormone that counteracts insulin’s glucose-lowering action by stimulating glycogenolysis and gluconeogenesis.
It is mapped to 2q36–2q37. GLP1 (7–37) encodes the preproglucagon molecule, rendering pancreatic beta-cells glucose-competent and may be useful in the treatment of noninsulin-dependent diabetes mellitus.
GLP1 is a potent insulin secretagogue and plays a major role in the enteroinsular axis, explaining why plasma insulin levels after oral glucose intake are higher than those observed after intravenous glucose administration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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