Thermo Fisher Scientific Avdoralimab Recombinant Human Monoclonal Antibody
Avdoralimab 재조합 인간 단일클론 항체로, C5AR1(CD88)을 표적으로 하는 연구용 항체입니다. ELISA 등 다양한 면역 분석에 사용 가능하며, 고순도 Protein A 정제 및 낮은 엔도톡신 수준을 보장합니다. 인체 유래 IgG1, kappa 형식으로 CHO 세포에서 발현된 액상 형태 제품입니다.
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Applications
- ELISA (Assay-dependent)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Human / IgG1, kappa |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Immunogen | Human C5AR1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.28 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2911405 |
Product Specific Information
- Endotoxin level < 0.01 EU/µg by LAL method
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- Store at 2–8°C for one week.
- Store at -20 to -80°C for twelve months from the date of receipt.
Target Information
Avdoralimab is a biosimilar that targets C5AR1 (CD88), a C5a Anaphylatoxin Receptor mediating potent chemotactic effects. C5AR1 expression has been reported in myeloid blood cells, brain, liver, lung, spleen, heart, kidney, and intestinal tract.
CD88 stimulates chemotaxis, granule enzyme release, and superoxide anion production. It is part of the classical complement cascade and may contribute to tissue injury in ischemia or sepsis.
Diseases associated with CD88 include Mannose-Binding Lectin Deficiency and Systemic Lupus Erythematosus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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