Thermo Fisher Scientific Avdoralimab Recombinant Human Monoclonal Antibody

Applications

• ELISA (Assay-dependent)

Product Specifications

Product Specific Information

• Endotoxin level < 0.01 EU/µg by LAL method
• Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
• Store at 2–8°C for one week.
• Store at -20 to -80°C for twelve months from the date of receipt.

Target Information

Avdoralimab is a biosimilar that targets C5AR1 (CD88), a C5a Anaphylatoxin Receptor mediating potent chemotactic effects. C5AR1 expression has been reported in myeloid blood cells, brain, liver, lung, spleen, heart, kidney, and intestinal tract.
CD88 stimulates chemotaxis, granule enzyme release, and superoxide anion production. It is part of the classical complement cascade and may contribute to tissue injury in ischemia or sepsis.
Diseases associated with CD88 include Mannose-Binding Lectin Deficiency and Systemic Lupus Erythematosus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.