Thermo Fisher Scientific KCNQ1 Polyclonal Antibody
KCNQ1 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체. Western blot 및 IHC(P) 응용에 적합하며 인간 및 설치류 반응성. 합성 펩타이드 면역원 사용, 액상 형태로 -20°C 보관. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1–3 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 6–8 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host/Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (EQLTVPRRGPDEGS) corresponding to the C-terminus amino acids of KCNQ1 (aa 663–676) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10981816 |
Product Specific Information
- Predicted to react with bovine, canine, mouse, and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 16,000.
Target Information
Voltage-gated K⁺ channels in the plasma membrane control the repolarization and frequency of action potentials in neurons, muscles, and other excitable cells.
KCNQ1, together with KCNE1, forms a channel predominantly expressed in the heart and cochlea, regulating slow depolarization-activated potassium currents.
Mutations in KCNQ1 or KCNE1 lead to cardiac disease due to impaired electrical signaling, while KCNQ4 mutations are linked to deafness.
KCNQ proteins, including KCNQ1 and KCNQ4, have six transmembrane domains and function as tetramers. KCNQ4 forms heteromeric channels with KCNQ3 and is expressed in various tissues, including cochlear outer hair cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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