Thermo Fisher Scientific PTHLH Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

-

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Published species

Not Applicable

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human PTHLH. Recombinant protein control fragment (Product #RP-89708). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PTHLH,uniProtId:P12272-1,ncbiNodeId:9606,antigenRange:35-157,antigenLength:177,antigenImageFileName:PA5-57493_PTHLH_P12272-1_Rabbit.svg,antigenImageFileNamePDP:PA5-57493_PTHLH_P12272-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.10 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2646113

Product Specific Information

Immunogen sequence: KRAVSEHQLL HDKGKSIQDL RRRFFLHHLI AEIHTAEIRA TSEVSPNSKP SPNTKNHPVR FGSDDEGRYL TQETNKVETY KEQPLKTPGK KKKGKPGKRK EQEKKKRRTR SAWLDSGVTG SGL

Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 24%.

Target Information

The protein encoded by this gene is a member of the parathyroid hormone family. This hormone regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. This hormone is involved in lactation possibly by regulating the mobilization and transfer of calcium to the milk. The receptor of this hormone, PTHR1, is responsible for most cases of humoral hypercalcemia of malignancy. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, in-frame and downstream of the initiator AUG codon, to give rise to nuclear forms of this hormone.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.