Thermo Fisher Scientific DNAJB14 Polyclonal Antibody
DNAJB14 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 응용에 적합합니다. 인간, 생쥐, 랫트 반응성이 있으며, 항원 친화 크로마토그래피로 정제되었습니다. 단백질 접힘 및 ERAD 경로 연구에 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human DNAJB14. Recombinant protein control fragment (Product #RP-96715). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2640680 |
Product Specific Information
- Immunogen sequence:
RKPSGSGDQS KPNCTKDSTS GSGEGGKGYT KDQVDGVLSI NKCKNYYEVL GVTKDAGDED - Highest antigen sequence identity to orthologs:
- Mouse: 87%
- Rat: 85%
Target Information
DNAJB14 acts as a co-chaperone with HSPA8/Hsc70, promoting protein folding and trafficking, preventing aggregation, and facilitating ERAD pathway processes (PubMed:24732912). It regulates HSPA8/Hsc70 ATPase and polypeptide-binding activities and can function independently with DNAJB12 to assist maturation of potassium channels KCND2 and KCNH2 (PubMed:27916661). Overexpression leads to formation of nuclear membranous structures (DJANGOs) with DNAJB12 and HSPA8/Hsc70, though their role remains unclear (PubMed:24732912). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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