Thermo Fisher Scientific Dectin 1 Polyclonal Antibody
Dectin-1(CLEC7A) 인식용 Rabbit Polyclonal Antibody로 인간 시료에 반응. WB, IHC, ICC/IF 등 다양한 응용 가능. 고순도 Affinity chromatography 정제, 액상 형태로 제공. 연구용으로만 사용.
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CLEC7A (Accession Q9BXN2), corresponding to amino acid residues A68–S118 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899745 |
Product Specific Information
Antibody detects endogenous levels of total Dectin-1.
Target Information
CLEC7A, also known as Dectin-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily and is predominantly expressed on myeloid cells. It is a small glycoprotein type II membrane receptor with an extracellular C-type lectin-like domain and a cytoplasmic domain containing an immunoreceptor tyrosine-based activation motif (ITAM).
CLEC7A functions as a pattern-recognition receptor that recognizes beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, playing a key role in innate immune response. Upon fungal exposure, CLEC7A activates Syk tyrosine kinase, triggering oxidative burst through reactive oxygen species formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: PA5-115109_Dectin_1_Clec7a_Q9BXN2-1_Rabbit.svg, PA5-115109_Dectin_1_Clec7a_Q9BXN2-1_Rabbit_PDP.jpeg)
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